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Article

Zebrafish unplugged reveals a role for muscle-specific kinase homologs in axonal pathway choice.

Nature neuroscience - 1 Dec 2004

Zhang Jing, Lefebvre Julie L, Zhao Shuxia, Granato Michael

Abstract excerpt

En route to their target, pioneering motor growth cones repeatedly encounter choice points at which they make pathway decisions. In the zebrafish mutant unplugged, two of the three segmental motor axons make incorrect decisions at a somitic choice point. Using positional cloning, we show here that unplugged encodes a homolog of muscle-specific kinase (MuSK) and that, unlike mammalian MuSK, unplugged has only a...

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Identifiers

PMID: 15543140
DOI: 10.1038/nn1350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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