Article
Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation.
Gut - 1 Dec 2004
Sturt N J H, Gallagher M C, Bassett P, Philp C R, Neale K F, Tomlinson I P M, Silver A R J, Phillips R K S
Abstract excerpt
BACKGROUND: Many patients with familial adenomatous polyposis (FAP) die from desmoid tumours which can arise spontaneously but often appear to be surgically induced by prophylactic colectomy. FAP results from germline adenomatous polyposis coli (APC) gene mutations and desmoids arise following biallelic APC mutation, with one change usually occurring distal to the second beta-catenin binding/degradation repeat of...
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