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Article

Defining absolute postoperative desmoid risk in familial adenomatous polyposis according to APC genotype and family history: retrospective cohort study.

BJS open - 4 Sept 2026

Zare Benjamin, Bahar Massih, Clark Susan, Latchford Andrew

Abstract excerpt

BACKGROUND: Desmoid disease is a major cause of morbidity and mortality in familial adenomatous polyposis (FAP), particularly after prophylactic colorectal surgery. Although APC genotype and family history are recognized risk factors, previous sizeable studies report relative rather than absolute risks. This study aimed to quantify absolute postoperative desmoid risk in FAP patients undergoing risk-reducing...

Read the complete abstract on PubMed

Topics

Humans
Adenomatous Polyposis Coli
Retrospective Studies
Female
Desmoid Tumors
Colectomy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Adult

Middle Aged

Risk Factors

Genotype

Postoperative Complications

Adenomatous Polyposis Coli Protein

Young Adult

Genes, APC

Source

Open in PubMed Open full text

Identifiers

PMID: 42765567
DOI: 10.1093/bjsopen/zrag090
PMCID: PMC13591399

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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