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Article

Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist.

Lancet (London, England) - 1 Jan 2000

Hoffman Hal M, Rosengren Sanna, Boyle David L, Cho Jae Y, Nayar Jyothi, Mueller James L, Anderson Justin P, Wanderer Alan A, Firestein Gary S

Abstract excerpt

BACKGROUND: Familial cold autoinflammatory syndrome (FCAS) is an autosomal dominant disorder characterised by recurrent episodes of rash, arthralgia, and fever after cold exposure. The genetic basis of this disease has been elucidated. Cryopyrin, the protein that is altered in FCAS, is one of the adaptor proteins that activate caspase 1, resulting in release of interleukin 1. METHODS: An experimental cold...

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Identifiers

PMID: 15541451
DOI: 10.1016/S0140-6736(04)17401-1
PMCID: PMC4321997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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