Article
A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 Trap) in patients with familial cold autoinflammatory syndrome.
Arthritis and rheumatism - 1 Aug 2008
Goldbach-Mansky Raphaela, Shroff Sharukh D, Wilson Mildred, Snyder Christopher, Plehn Sara, Barham Beverly, Pham Tuyet-Hang, Pucino Frank, Wesley Robert A, Papadopoulos Joanne H, Weinstein Steven P, Mellis Scott J, Kastner Daniel L
Abstract excerpt
OBJECTIVE: Familial cold autoinflammatory syndrome (FCAS) is caused by mutations in the CIAS1 gene, leading to excessive secretion of interleukin-1beta (IL-1beta), which is associated with cold-induced fevers, joint pain, and systemic inflammation. This pilot study was conducted to assess the saf...
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