Article
Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus.
Vision research - 1 Dec 2004
Pinto Lawrence H, Vitaterna Martha Hotz, Siepka Sanda M, Shimomura Kazuhiro, Lumayag Stephen, Baker Matthew, Fenner Deborah, Mullins Robert F, Sheffield Val C, Stone Edwin M, Heffron Edward, Takahashi Joseph S
Abstract excerpt
Random mutagenesis combined with phenotypic screening using carefully crafted functional tests has successfully led to the discovery of genes that are essential for a number of functions. This approach does not require prior knowledge of the identity of the genes that are involved and is a way to ascribe function to the nearly 6000 genes for which knowledge of the DNA sequence has been inadequate to determine the...
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