Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exposure of human lymphocytes and lymphoblastoid cells to simulated microgravity strongly affects energy metabolism and DNA repair

8 Nov 2004

Abstract excerpt

Exposure of freshly drawn lymphocytes and lymphoblastoid cells (LB and COR3) to simulated microgravity decreased the intracellular ATP concentration to 50%-40% of the value found in normal growth conditions. The decrease was reversible although recovery to normal values occurred only slowly both in lymphocytes and in lymphoblastoid cells. Poly(ADP-ribose) polymerase (PARP ) activity was increased indicating that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetics, Aging, and Longevity in Model Organisms
Share to Radiation Therapy and Dosimetry
Share to Spaceflight effects on biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15534877
DOI: 10.1002/jcb.20302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exposure of human lymphocytes and lymphoblastoid cells to simulated microgravity strongly affects energy metabolism and DNA repairPMID 15534877Read ↗

Simulated microgravity decreases DNA repair capacity and induces DNA damage in human lymphocytesSemantic proximity Read ↗

The Influence of Microgravity on Repair of Radiation-Induced DNA Damage in Bacteria and Human FibroblastsSemantic proximity Read ↗

Simultaneous Exposure of Cultured Human Lymphoblastic Cells to Simulated Microgravity and Radiation Increases Chromosome AberrationsSemantic proximity Read ↗

DNA repair in modeled microgravity: Double strand break rejoining activity in human lymphocytes irradiated with γ-raysSemantic proximity Read ↗

Modeled microgravity affects cell survival and HPRT mutant frequency, but not the expression of DNA repair genes in human lymphocytes irradiated with ionising radiation.Semantic proximity Read ↗

Cellular responses and gene expression profile changes due to bleomycin-induced DNA damage in human fibroblasts in spaceSemantic proximity Read ↗

Microgravity-Induced Changes to Drug Response in Cancer Cells Quantified Using Fluorescence MorphometrySemantic proximity Read ↗

Simulated Microgravity-Induced Changes to Drug Response in Cancer Cells Quantified Using Fluorescence MorphometrySemantic proximity Read ↗

Spaceflight alters microtubules and increases apoptosis in human lymphocytes (Jurkat)Semantic proximity Read ↗

T cell regulation in microgravity – The current knowledge from in vitro experiments conducted in space, parabolic flights and ground-based facilitiesSemantic proximity Read ↗

Interleukin-6 Expression under Gravitational Stress Due to Vibration and Hypergravity in Follicular Thyroid Cancer CellsSemantic proximity Read ↗

Radiation-induced chromosome damage in astronauts' lymphocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.