Modeled microgravity affects cell survival and HPRT mutant frequency, but not the expression of DNA repair genes in human lymphocytes irradiated with ionising radiation.

Abstract excerpt

We analysed the possibility that a reduced gravitational force impairs the efficiency of DNA repair, increasing the risk of the exposure to conditions occurring during spaceflight: i.e., ionising radiation and microgravity. To obtain information on the effects of the reduced gravity in repairing DNA damage induced by radiation, we compared cell survival and mutant frequency at the hypoxanthine-guanine...

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