Article
Mitochondrial DNA 3644T-->C mutation associated with bipolar disorder.
Genomics - 1 Dec 2004
Munakata Kae, Tanaka Masashi, Mori Kanako, Washizuka Shinsuke, Yoneda Makoto, Tajima Osamu, Akiyama Tsuyoshi, Nanko Shinichiro, Kunugi Hiroshi, Tadokoro Kazuyuki, Ozaki Norio, Inada Toshiya, Sakamoto Kaoru, Fukunaga Takako, Iijima Yoshimi, Iwata Nakao, Tatsumi Masahiko, Yamada Kazuo, Yoshikawa Takeo, Kato Tadafumi
Abstract excerpt
Mitochondrial dysfunction associated with mutant mitochondrial DNA (mtDNA) has been suggested in bipolar disorder, and comorbidity with neurodegenerative diseases was often noted. We examined the entire sequence of mtDNA in six subjects with bipolar disorder having comorbid somatic symptoms suggestive of mitochondrial disorders and found several uncharacterized homoplasmic nonsynonymous nucleotide substitutions...
Topics
- Adolescent
- Adult
- Bipolar Disorder
- Case-Control Studies
- DNA, Mitochondrial
- Electron Transport Complex I
- Female
- Humans
- Hybrid Cells
- Male
- Membrane Potentials
- Middle Aged
- Mitochondria