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Article

A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam.

Brain & development - 1 Dec 2004

Kosaki Kenjiro, Tamura Kazuyo, Sato Reiko, Samejima Hazuki, Tanigawara Yusuke, Takahashi Takao

Abstract excerpt

N-desmethylclobazam (N-CLB), the major metabolite of clobazam (CLB), exerts a large influence on therapeutic and adverse effects of CLB. A substantial inter-individual variability has been observed in the ratios of N-CLB concentration/CLB dose and of the N-CLB/CLB concentration. We document here...

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Source

Identifiers

PMID: 15533655
DOI: 10.1016/j.braindev.2004.02.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15533655-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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