Article
Large BRCA1 gene deletions are found in 3% of German high-risk breast cancer families.
Human mutation - 1 Dec 2004
Hartmann Carolin, John Anika L, Klaes Rüdiger, Hofmann Wera, Bielen Rainer, Koehler Rolf, Janssen Bart, Bartram Claus R, Arnold Norbert, Zschocke Johannes
Abstract excerpt
We have tested for large BRCA1 gene rearrangements in German high-risk breast and ovarian cancer families previously screened negative for point mutations by dHPLC and sequencing. Using the novel MLPA method, two deletions of exons 1A, 1B and 2 and exon 17, respectively, were detected in four out of 75 families investigated in Southern Germany. An identical exon 17 deletion with the same breakpoints and a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.