Article
Large BRCA1 and BRCA2 genomic rearrangements in Danish high risk breast-ovarian cancer families.
Breast cancer research and treatment - 1 May 2009
Hansen Thomas v O, Jønson Lars, Albrechtsen Anders, Andersen Mette K, Ejlertsen Bent, Nielsen Finn C
Abstract excerpt
BRCA1 and BRCA2 germ-line mutations predispose to breast and ovarian cancer. Large genomic rearrangements of BRCA1 account for 0-36% of all disease causing mutations in various populations, while large genomic rearrangements in BRCA2 are more rare. We examined 642 East Danish breast and/or ovarian cancer patients in whom a deleterious mutation in BRCA1 and BRCA2 was not detected by sequencing using the multiplex...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.