Article
Multifactorial Regulation of Myometrial Contractility During Pregnancy and Parturition
25 Oct 2019
Abstract excerpt
The steroid hormones progesterone (P4) and estradiol-17b (E2), produced by the placenta in humans and the ovaries in rodents, serve crucial roles in the maintenance of pregnancy and the initiation of parturition. Because of their critical importance for species survival, the mechanisms whereby P4 and its nuclear receptor (PR) maintain myometrial quiescence during pregnancy and for the decline in P4/PR and...
