Article
Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation.
Proceedings of the National Academy of Sciences of the United States of America - 12 Nov 2002
Le Dean A, Wu Yongqin, Huang Zhihong, Matsushita Kohji, Plesnila Nikolaus, Augustinack Jean C, Hyman Bradley T, Yuan Junying, Kuida Keisuke, Flavell Richard A, Moskowitz Michael A
Abstract excerpt
Caspase-3 is a major cell death effector protease in the adult and neonatal nervous system. We found a greater number and higher density of cells in the cortex of caspase-3(-/-) adult mice, consistent with a defect in developmental cell death. Caspase-3(-/-) mice were also more resistant to ischemic stress both in vivo and in vitro. After 2 h of ischemia and 48 h of reperfusion, cortical infarct volume was...
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