Article
ACE gene titration in mice uncovers a new mechanism for ACE on the control of body weight.
Physiological genomics - 20 Jan 2005
Heimann A S, Favarato M H, Gozzo F C, Rioli V, Carreño F R, Eberlin M N, Ferro E S, Krege J H, Krieger J E
Abstract excerpt
Mice harboring 1, 2, or 3 copies of the angiotensin-converting enzyme (ACE) gene were used to evaluate the quantitative role of the ACE locus on obesity. Three-copy mice fed with a high-fat diet had lower body weight and peri-epididymal adipose tissue than did 1- and 2-copy mice (P < 0.05). On re...
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