Article
FRG2, an FSHD candidate gene, is transcriptionally upregulated in differentiating primary myoblast cultures of FSHD patients.
Journal of medical genetics - 1 Nov 2004
Rijkers T, Deidda G, van Koningsbruggen S, van Geel M, Lemmers R J L F, van Deutekom J C T, Figlewicz D, Hewitt J E, Padberg G W, Frants R R, van der Maarel S M
Abstract excerpt
BACKGROUND: Autosomal dominant facioscapulohumeral muscular dystrophy (FSHD) is associated with partial deletion of the subtelomeric D4Z4 repeat array on chromosome 4qter. This chromosomal rearrangement may result in regional chromatin relaxation and transcriptional deregulation of genes nearby. METHODS AND RESULTS: Here we describe the isolation and characterisation of FRG2, a member of a chromosomally dispersed...
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