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Nonrandom Dimerization of Murine Leukemia Virus Genomic RNAs

26 Oct 2004

Abstract excerpt

Retroviral genomes consist of two unspliced RNAs linked noncovalently in a dimer. Although these two RNAs are generally identical, two different RNAs can be copackaged when virions are produced by coinfected cells. It has been assumed, but not tested, that copackaging results from random RNA associations in the cytoplasm to yield encapsidated RNA homodimers and heterodimers in Hardy-Weinberg proportions. Here,...

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PMID: 15507599
DOI: 10.1128/jvi.78.22.12129-12139.2004

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