Article
Inflammatory response and the endothelium.
Thrombosis research - 1 Jan 2004
Meroni P L, Borghi M O, Raschi E, Ventura D, Sarzi Puttini P C, Atzeni F, Lonati L, Parati G, Tincani A, Mari D, Tedesco F
Abstract excerpt
Antiphospholipid-mediated endothelium perturbation plays a role in antiphospholipid syndrome (APS)-associated vasculopathy. Antiphospholipid antibodies activate endothelium both in vitro and in vivo experimental models by inducing a pro-inflammatory/-coagulant phenotype; the antibodies recognize beta2 glycoprotein I (beta2GPI) on human endothelial cells (EC) from different parts of the vasculature. In spite of...
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