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Article

Cloning, analysis, and heterologous expression of a polyketide synthase gene cluster of Streptomyces curacoi.

Biotechnology and applied biochemistry - 1 Feb 1992

Bergh S, Uhlén M

Abstract excerpt

Streptomyces curacoi produces curamycin, an antibiotic based on a modified orsellinic acid skeleton that is synthesized by the polyketide pathway. We have cloned, characterized, and partly sequenced a polyketide synthase gene cluster of S. curacoi. The sequence data reveal an organization of open reading frames that is similar to those of other polyketide synthetic clusters, although the biosynthetic products...

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Identifiers

PMID: 1550661
DOI: 10.1111/j.1470-8744.1992.tb00197.x

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