Diabetes (db/db) mutation-induced endometrial epithelial lipoapoptosis: ultrastructural and cytochemical analysis of reproductive tract atrophy.

doi:10.1186/1477-7827-3-15

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Article

Diabetes (db/db) mutation-induced endometrial epithelial lipoapoptosis: ultrastructural and cytochemical analysis of reproductive tract atrophy.

Reproductive biology and endocrinology : RB&E - 27 Apr 2005

Garris David R

Abstract excerpt

BACKGROUND: The diabetes (db/db) mutation in C57BL/KsJ mice promotes a progressive cytolipidemia within the endometrial epithelial (EE) layer of the female reproductive tract which results in premature cellular and organ atrophy. The current studies focus on the ultrastructural and cytochemical changes which promote nuclear apoptosis and cytostructural disruption following the expression of endometrial...

Topics

Animals
Apoptosis
Atrophy
Diabetes Complications
Diabetes Mellitus, Type 2
Endometrium
Epithelial Cells
Female
Genetic Predisposition to Disease
Hyperglycemia
Lipid Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Obese

Microscopy, Electron, Transmission

Models, Biological

Mutation

Phenotype

Uterine Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 15857516
DOI: 10.1186/1477-7827-3-15
PMCID: PMC1097758

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