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Article

Chaotic genomes make chaotic cells: the mutator phenotype theory of carcinogenesis applied to clinicopathological relationships of solid tumors.

Cancer investigation - 1 Jan 2004

Bignold L P

Abstract excerpt

Abnormalities of cell morphology and chromosomes have been identified as features of the pathology of tumors for more than 100 years. However, no theory of carcinogenesis until recently has provided a basis for relating them either to each other or to the clinical behavior of individual tumors in many patients. The mutator phenotype theory is based on large numbers of mutations occurring chaotically (randomly,...

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PMID: 15493353
DOI: 10.1081/cnv-200029056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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