Article
Tissue factor promotor polymorphism -603 A/G is associated with myocardial infarction.
Atherosclerosis - 1 Nov 2004
Ott Ilka, Koch Werner, von Beckerath Nicolas, de Waha Rene, Malawaniec Anna, Mehilli Julinda, Schömig Albert, Kastrati Adnan
Abstract excerpt
Tissue factor (TF), the main initiator of the extrinsic coagulation cascade is expressed in atherosclerotic lesions and contributes to coronary thrombus formation in myocardial infarction (MI). Circulating TF reflects intravascular TF activation but also adds to prothrombotic activation. Because the G allele of the TF promotor polymorphism -603 A/G is associated with monocytic mRNA expression we evaluated its...
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