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Article

Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease.

Journal of neurochemistry - 1 Nov 2004

Angulo Ester, Noé Véronique, Casadó Vicent, Mallol Josefa, Gomez-Isla Teresa, Lluis Carmen, Ferrer Isidre, Ciudad Carlos J, Franco Rafael

Abstract excerpt

Gene expression throughout the different stages of Alzheimer's disease was analysed in samples from cerebral cortex. The gene encoding the voltage-gated potassium channel Kv3.4 was already overexpressed in early stages of the disease, and in advanced stages Kv3.4 was present at high levels in neurodegenerative structures. This subunit regulates delayed-rectifier currents, which are primary determinants of spike...

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Identifiers

PMID: 15485486
DOI: 10.1111/j.1471-4159.2004.02771.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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