Article
Phenotypical and molecular profiling of the extraneuronal cholinergic system of the skin.
The Journal of investigative dermatology - 1 Nov 2004
Kurzen Hjalmar, Berger Hans, Jäger Claudia, Hartschuh Wolfgang, Näher Helmut, Gratchev Alexei, Goerdt Sergij, Deichmann Martin
Abstract excerpt
We present molecular and protein profiling of all acetylcholine receptors (ACh-R) in human scalp skin using PCR, in situ hybridization and double-labeling immunofluorescence. Within the epidermis, the nicotinic (n)ACh-R subunits, alpha3, alpha5, beta2, and beta4 were expressed in the basal cell layer (BCL) and in a single cell layer in the stratum granulosum; alpha9 was expressed in the basal and lower spinous...
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