Article
Roles of conserved and allelic regions of the major merozoite surface protein (gp195) in immunity against Plasmodium falciparum.
Infection and immunity - 1 Apr 1992
Hui G S, Hashimoto A, Chang S P
Abstract excerpt
The Plasmodium falciparum major merozoite surface protein gp195 is a candidate antigen for a vaccine against human malaria. The significance of allelism and polymorphism in vaccine-induced immunity to gp195 was investigated in this study. Rabbits were immunized with each of two allelic forms of gp195 that were affinity purified from the FUP and FVO parasite isolates. gp195-specific antibodies raised against one...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antibodies, Protozoan
- Antigens, Protozoan
- Base Sequence
- Binding, Competitive
- Blotting, Western
- Dose-Response Relationship, Immunologic
- Enzyme-Linked Immunosorbent Assay