Article
Association between exercise and pubertal BMD is modulated by estrogen receptor alpha genotype.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2004
Suuriniemi Miia, Mahonen Anitta, Kovanen Vuokko, Alén Markku, Lyytikäinen Arja, Wang Qingju, Kröger Heikki, Cheng Sulin
Abstract excerpt
UNLABELLED: Genetic and environmental factors contribute to bone mass, but the ways they interact remain poorly understood. This study of 245 pre- and early pubertal girls found that the PvuII polymorphism in the ER-alpha gene modulates the effect of exercise on BMD at loaded bone sites. INTRODUCTION: Impaired achievement of bone mass at puberty is an important risk factor for the development of osteoporosis in...
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