Article
NVL2 is a nucleolar AAA-ATPase that interacts with ribosomal protein L5 through its nucleolar localization sequence.
Molecular biology of the cell - 1 Dec 2004
Nagahama Masami, Hara Yoshimitsu, Seki Akihiro, Yamazoe Takeshi, Kawate Yumiko, Shinohara Takashi, Hatsuzawa Kiyotaka, Tani Katsuko, Tagaya Mitsuo
Abstract excerpt
NVL (nuclear VCP-like protein), a member of the AAA-ATPase family, is known to exist in two forms with N-terminal extensions of different lengths in mammalian cells. Here, we show that they are localized differently in the nucleus; NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Mutational analysis demonstrated the presence of two nuclear localization signals in NVL2,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.