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Article

E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma.

Oncogene - 11 Nov 2004

Saito Tsuyoshi, Oda Yoshinao, Kawaguchi Ken-ichi, Sugimachi Keishi, Yamamoto Hidetaka, Tateishi Naomi, Tanaka Kazuhiro, Matsuda Shuichi, Iwamoto Yukihide, Ladanyi Marc, Tsuneyoshi Masazumi

Abstract excerpt

We have recently reported frequent E-cadherin gene mutations in synovial sarcoma (SS), suggesting mutational inactivation of E-cadherin as a potential mechanism of spindle cell morphology in SS, a spindle cell sarcoma that shows areas of glandular epithelial differentiaton in some cases (biphasic SS) and only pure spindle cell morphology in most cases (monophasic SS). However, the mechanism of downregulation of...

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Source

Identifiers

PMID: 15467754
DOI: 10.1038/sj.onc.1207960

Genes

ELF3
SSX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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