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Article

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease.

Journal of the American College of Cardiology - 6 Oct 2004

Hovingh G Kees, Brownlie Alison, Bisoendial Radjesh J, Dube Marie Pierre, Levels Johannes H M, Petersen Wilma, Dullaart Robin P F, Stroes Erik S G, Zwinderman Aeilko H, de Groot Eric, Hayden Michael R, Kuivenhoven Jan Albert, Kastelein John J P

Abstract excerpt

OBJECTIVES: We investigated the consequences of an apolipoprotein A-I (apoA-I) gene defect with regard to lipid metabolism, endothelial function, arterial wall thickness, and coronary artery disease (CAD) risk. BACKGROUND: Due to limited numbers of carriers of the apoA-I defects, data on the cons...

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Source

Identifiers

PMID: 15464323
DOI: 10.1016/j.jacc.2004.06.070

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15464323-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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