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Article

Visualization of SHP-1-target interaction.

Journal of cell science - 1 Oct 2004

Biskup Christoph, Böhmer Annette, Pusch Rico, Kelbauskas Laimonas, Gorshokov Alexander, Majoul Irina, Lindenau Jörg, Benndorf Klaus, Böhmer Frank-D

Abstract excerpt

Signaling of receptor tyrosine kinases (RTKs) is regulated by protein-tyrosine phosphatases (PTPs). We previously discovered the efficient downregulation of Ros RTK signaling by the SH2 domain PTP SHP-1, which involves a direct interaction of both molecules. Here, we studied the mechanism of this interaction in detail. Phosphopeptides representing the SHP-1 candidate binding sites in the Ros cytoplasmic domain,...

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Identifiers

PMID: 15456853
DOI: 10.1242/jcs.01397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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