Article
The secreted protease factor CPAF is responsible for degrading pro-apoptotic BH3-only proteins in Chlamydia trachomatis-infected cells.
The Journal of biological chemistry - 20 Oct 2006
Pirbhai Mustak, Dong Feng, Zhong Youmin, Pan Kelvin Z, Zhong Guangming
Abstract excerpt
Chlamydia trachomatis has evolved a profound anti-apoptotic activity that may aid in chlamydial evasion of host defense. The C. trachomatis anti-apoptotic activity has been correlated with blockade of mitochondrial cytochrome c release, inhibition of Bax and Bak activation, and degradation of BH3-only proteins. This study presents evidence that a chlamydia-secreted protease factor designated CPAF is both...
Topics
- Apoptosis
- Apoptosis Regulatory Proteins
- Cell-Free System
- Chlamydia trachomatis
- Glutathione Transferase
- HeLa Cells
- Humans
- Mutation
- Platelet Activating Factor
- Protein Binding
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- Recombinant Proteins