Article
Hypoxia modulates adenosine receptors in human endothelial and smooth muscle cells toward an A2B angiogenic phenotype.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2004
Feoktistov Igor, Ryzhov Sergey, Zhong Hongyan, Goldstein Anna E, Matafonov Anton, Zeng Dewan, Biaggioni Italo
Abstract excerpt
We previously reported that adenosine A2B receptor activation stimulates angiogenesis. Because hypoxia is a potent stimulus for the release of both adenosine and angiogenic factors, we tested the hypothesis that hypoxia alters the expression of adenosine receptors toward an "angiogenic" phenotype. We used human umbilical vein endothelial cells (HUVECs) and bronchial smooth muscle cells (BSMCs) because, under...
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