Article
Positive selection for loss of RpoS function in Escherichia coli.
Mutation research - 4 Oct 2004
Chen Guozhu, Patten Cheryl L, Schellhorn Herb E
Abstract excerpt
Though RpoS, an alternative sigma factor, is required for survival and adaptation of Escherichia coli under stress conditions, many strains have acquired independent mutations in the rpoS gene. The reasons for this apparent selective loss and the nature of the selective agent are not well understood. In this study, we found that some wild type strains grow poorly in succinate minimal media compared with isogenic...
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