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Article

Transcriptional profiling in an MPNST-derived cell line and normal human Schwann cells

1 May 2004

Abstract excerpt

cDNA microarrays were utilized to identify abnormally expressed genes in a malignant peripheral nerve sheath tumor (MPNST)-derived cell line, T265, by comparing the mRNA abundance profiles with that of normal human Schwann cells (nhSCs). The findings characterize the molecular phenotype of this important cell-line model of MPNSTs, and elucidate the contribution of Schwann cells in MPNSTs. In total, 4608 cDNA...

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PMID: 16429615
DOI: 10.1017/s1740925x04000274

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