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Expression of Concern: Gene expression profile activated by the chemokine CCL5/RANTES in human neuronal cells

23 Aug 2004

Abstract excerpt

Differentiated human NT2-N neurons were shown to express CCR5 and CXCR4 chemokine receptor mRNA and protein, and to be responsive to the chemokines CCL5 and CXCL12. Using cDNA microarray technology, CCL5 was found to induce a distinct transcriptional program, with reproducible induction of 46 and 9 genes after 2 and 8 hr of treatment, respectively. Conversely, downregulation of 20 and 7 genes was observed after 2...

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PMID: 15389840
DOI: 10.1002/jnr.20250

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