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JC Virus-Induced Changes in Cellular Gene Expression in Primary Human Astrocytes

11 Sept 2003

Abstract excerpt

Cell-type-specific transcription of the JC virus (JCV) promoter in glial cells initiates a series of events leading to viral replication in the brain and the development of the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML) in patients with neurologic complications due to infection with human immunodeficiency virus type 1. Here we employed an in vitro infection of primary cultures of...

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PMID: 12970448
DOI: 10.1128/jvi.77.19.10638-10644.2003

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