Article
Dynamics of gene silencing by RNA interference.
Biotechnology and bioengineering - 5 Oct 2004
Raab R Michael, Stephanopoulos Gregory
Abstract excerpt
The large number of candidate genes identified by modern high-throughput technologies require efficient methods for generating knockout phenotypes or gene silencing in order to study gene function. RNA interference (RNAi) is an efficient method that can be used for this purpose. Effective gene silencing by RNAi depends on a number of important parameters, including the dynamics of gene expression and the RNA...
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