Article
Effects of ciprofloxacin on the stereoselective disposition of mexiletine in man.
Therapeutic drug monitoring - 1 Oct 2004
Labbé Line, Robitaille N Michelle, Lefez Christophe, Potvin Diane, Gilbert Marcel, O'Hara Gilles, Turgeon Jacques
Abstract excerpt
Mexiletine is extensively metabolized in man, with less than 10% of the dose being excreted unchanged in urine. Clinical drug-drug interaction studies as well as in vitro drug metabolism studies suggest that CYP1A2, in addition to CYP2D6, is involved in the metabolism of mexiletine in man. Therefore, the objective of the study was to determine whether potential inhibition of CYP1A2 by the quinolone antibiotic...
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