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Article

The expression of P‐glycoprotein in AML cells with <i>FLT3</i> internal tandem duplications is associated with reduced apoptosis in response to FLT3 inhibitors

24 Aug 2004

Abstract excerpt

P-glycoprotein (pgp), a membrane efflux pump, is recognized to have an anti-apoptotic function. Internal tandem duplications (ITDs) of the Fms-like tyrosine kinase 3 (FLT3) receptor are the most common mutations in acute myeloid leukaemia (AML). Both ITDs and pgp positivity confer an adverse clinical prognosis. FLT3 inhibitors induce variable apoptosis in cell lines transfected with FLT3 ITDs. We studied the...

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PMID: 15384974
DOI: 10.1111/j.1365-2141.2004.05145.x

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