Ponatinib may overcome resistance of <scp>FLT</scp>3‐<scp>ITD</scp> harbouring additional point mutations, notably the previously refractory <scp>F</scp>691I mutation

Abstract excerpt

Fms-like tyrosine kinase (FLT3) mutations are the most frequent mutations in patients with acute myeloid leukaemia (AML) that confer a poor prognosis. Constitutively active FLT3-ITD (internal tandem duplications) mutations define a promising target for therapeutic approaches using small molecule inhibitors. However, several point mutations of the FLT3 tyrosine kinase domain (FLT3-TKD) have been identified to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acute Myeloid Leukemia Research
• Share to Chronic Myeloid Leukemia Treatments
• Share to Myeloproliferative Neoplasms: Diagnosis and Treatment