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ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV

1 Nov 2020

Abstract excerpt

Angiotensin converting enzyme (ACE) is well-known for its role in blood pressure regulation via the renin-angiotensin aldosterone system (RAAS) but also functions in fertility, immunity, haematopoiesis and diseases such as obesity, fibrosis and Alzheimer's dementia. Like ACE, the human homologue ACE2 is also involved in blood pressure regulation and cleaves a range of substrates involved in different...

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PMID: 33146371
DOI: 10.1042/cs20200899

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