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Article

Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis.

Circulation journal : official journal of the Japanese Circulation Society - 1 Mar 2010

Imai Yumiko, Kuba Keiji, Ohto-Nakanishi Takayo, Penninger Josef M

Abstract excerpt

Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin-angiotensin system by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. For instance, in the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis,...

Topics

Angiotensin-Converting Enzyme 2
Cardiovascular Diseases
Humans
Mutation
Peptidyl-Dipeptidase A
Renin-Angiotensin System
Respiratory Distress Syndrome
Severe Acute Respiratory Syndrome

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20134095
DOI: 10.1253/circj.cj-10-0045

Genes

ACE2
ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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