Article
Low virulent strains of Candida albicans: unravelling the antigens for a future vaccine.
Proteomics - 1 Oct 2004
Fernández-Arenas Elena, Molero Gloria, Nombela César, Diez-Orejas Rosalía, Gil Concha
Abstract excerpt
Several low virulent Candida albicans mutant strains: CM1613 (deleted in the Mitogen Activated Protein (MAP) Kinase MKC1), CNC13 (deleted in the MAP-kinase HOG1) and the morphological mutant 92' were used as vaccines employing a murine model of systemic candidiasis. In this vaccination trial, only the CNC13 strain was able to induce protection against a subsequent infection with a lethal dose of the wild-type...
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