Article
Immunoproteomic analysis of the protective response obtained from vaccination with Candida albicans ecm33 cell wall mutant in mice.
Proteomics - 1 Jul 2008
Martínez-López Raquel, Nombela César, Diez-Orejas Rosalía, Monteoliva Lucía, Gil Concha
Abstract excerpt
Systemic candidiasis remains a major cause of disease and death, particularly among immunocompromised patients. The cell wall of Candida albicans defines the interface between host and pathogen and surface proteins are major elicitors of host immune responses during candidiasis. The C. albicans ecm33 mutant (RML2U) presents an altered cell wall, which entails an increase in the outermost protein layer....
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