Article
Mutation of the WI-1 gene yields an attenuated blastomyces dermatitidis strain that induces host resistance.
The Journal of clinical investigation - 1 Dec 2000
Wüthrich M, Filutowicz H I, Klein B S
Abstract excerpt
Systemic fungal infections are becoming more common and difficult to treat, and vaccine prevention is not available. Pulmonary infection with the dimorphic fungus Blastomyces dermatitidis often progresses and requires treatment to prevent fatality. We recently created a recombinant strain of the fungus lacking the WI-1 adhesin and pathogenicity. We show here that administration of viable yeast of this attenuated...
Topics
- Adoptive Transfer
- Animals
- Blastomyces
- Blastomycosis
- CD4-Positive T-Lymphocytes
- Fungal Proteins
- Fungal Vaccines
- Glycoproteins
- Hypersensitivity, Delayed
- Interferon-gamma
- Lung Diseases, Fungal
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL