Article
p53 overexpression and mutation in metaplastic carcinoma of the breast: genetic evidence for a monoclonal origin of both the carcinomatous and the heterogeneous sarcomatous components.
The Journal of pathology - 1 Oct 2004
Lien Huang-Chun, Lin Chung-Wu, Mao Tsui-Lien, Kuo Sung-Hsin, Hsiao Cheng-Hsiang, Huang Chiun-Sheng
Abstract excerpt
Metaplastic carcinoma of the breast (MCB) is characterized by the biphasic presence of both a carcinomatous component (CC) and heterogeneous sarcomatous components (HSCs). Although an epithelial or myoepithelial origin of the HSCs has been suggested, molecular evidence for a common origin for the CC and HSCs is limited and the mechanism underlying the sarcomatous or metaplastic change is unknown. The present...
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