Article
Mutational, epigenetic and expressional analyses of caveolin-1 gene in breast cancers.
International journal of molecular medicine - 1 Oct 2004
Chen Shou-Tung, Lin Syh-Yi, Yeh Kun-Tu, Kuo Shou-Jen, Chan Wen-Ling, Chu Yen-Ping, Chang Jan-Gowth
Abstract excerpt
Caveolin-1, an integral membrane protein of caveolae found in many cell types, has been suggested as a candidate tumor suppressor. However, the mechanism underlying caveolin-1 decreased expression is not fully understood. The purpose of this study is to investigate the role of aberrant promoter methylation in the regulation of caveolin-1 gene in breast cancer correlated with clinical findings. We used methylation...
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