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Article

Telomerase Expression Predicts Unfavorable Outcome in Osteosarcoma

13 Sept 2004

Abstract excerpt

PURPOSE: Osteosarcoma is distinct from most cancers in that the majority of osteosarcomas lack telomerase expression and use the alternative lengthening of telomeres (ALT) mechanism to maintain telomeres. Laboratory studies suggest that compared with ALT, telomerase expression is associated with increased tumor aggressiveness. We evaluated the clinical significance of telomerase expression in human osteosarcoma....

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Identifiers

PMID: 15365076
DOI: 10.1200/jco.2004.03.043

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