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Article

Are respiratory enzymes the primary sources of intracellular hydrogen peroxide?

The Journal of biological chemistry - 19 Nov 2004

Seaver Lauren Costa, Imlay James A

Abstract excerpt

Endogenous H2O2 is believed to be a source of chronic damage in aerobic organisms. To quantify H2O2 formation, we have generated strains of Escherichia coli that lack intracellular scavenging enzymes. The H2O2 that is formed within these mutants diffuses out into the medium, where it can be measured. We sought to test the prevailing hypothesis that this H2O2 is primarily generated by the autoxidation of redox...

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Identifiers

PMID: 15361522
DOI: 10.1074/jbc.M408754200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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