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Evolutionary analysis of 11β‐hydroxysteroid dehydrogenase‐type 1, ‐type 2, ‐type 3 and 17β‐hydroxysteroid dehydrogenase‐type 2 in fish

21 Aug 2004

Abstract excerpt

Steroid dehydrogenases regulate the access of active steroids to their receptors. In particular, 11beta-hydroxysteroid dehydrogenase-type 1 (11beta-HSD1) and 11beta-HSD2 regulate the levels of glucocorticoids, such as cortisol, and 17beta-HSD1 and 17beta-HSD2 regulate the levels of androgens and estrogens. Human 11beta-HSD1 and 11beta-HSD2 are distant homologs, with less than 25% amino acid sequence identity, as...

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PMID: 15358559
DOI: 10.1016/j.febslet.2004.08.023

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